Neuroimaging studies in chronic PTSD have consistently shown volume reduction in which brain structure?

• A Caudate nucleus
• B Corpus callosum
• C Globus pallidus
• D Hippocampus ✓

Explanation

Meta-analyses show reduced hippocampal volume in chronic PTSD, attributed to glucocorticoid neurotoxicity and stress-induced neuronal atrophy. The hippocampus is critical for contextual memory and fear extinction. This finding is one of the most replicated neuroimaging observations in PTSD and is discussed in standard neuroscience and psychiatry texts.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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