Which pair of SSRIs carries formal regulatory approval specifically for the treatment of post-traumatic stress disorder?

• A Fluoxetine and fluvoxamine
• B Sertraline and fluvoxamine
• C Escitalopram and citalopram
• D Sertraline and paroxetine ✓

Explanation

Only sertraline and paroxetine hold regulatory approval for PTSD among the SSRIs, and both are recommended as first-line pharmacotherapy by practice guidelines. Other SSRIs such as fluoxetine and escitalopram are widely used off label and have supportive trial data, but they lack the specific approval. This fact also explains why sertraline appears so often as the standard first choice in PTSD examination items.

Reference: Kaplan and Sadock's Synopsis of Psychiatry, 12th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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