Under the National TB Elimination Programme, a newly diagnosed adult with drug-sensitive pulmonary tuberculosis and no additional risk factors is prescribed the standard first-line regimen. Which schedule is correct?
- A 2 months HRZE followed by 4 months HR, all doses thrice weekly
- B 2 months HRZE followed by 4 months HR, all doses daily ✓
- C 2 months HRZ followed by 4 months HR, alternate-day dosing
- D 6 months of HRZE continuously, then 3 months of HR
Correct answer: B. 2 months HRZE followed by 4 months HR, all doses daily
Explanation
The NTEP regimen for new drug-sensitive TB is 2HRZE in the intensive phase followed by 4HR in the continuation phase, with all doses given daily under supervision. Thrice-weekly intermittent therapy was abandoned after evidence showed inferior outcomes and acquired rifampicin resistance compared with daily dosing. Ethambutol is included in the intensive phase of every new case, so regimens omitting it are incorrect.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
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