Following the withdrawal of trivalent oral polio vaccine, India introduced fractional doses of inactivated polio vaccine into routine immunisation. Which statement about fractional IPV (fIPV) is correct?
- A It is given as 0.1 mL subcutaneously in the upper arm
- B It is given as 0.1 mL intradermally in the upper arm at 6 and 14 weeks ✓
- C It is given as 0.1 mL intradermally using a needle-free injector
- D It is given as 0.5 mL intramuscularly in the anterolateral thigh
Correct answer: B. It is given as 0.1 mL intradermally in the upper arm at 6 and 14 weeks
Explanation
Fractional IPV uses one fifth of the full dose, that is 0.1 mL, administered intradermally in the right upper arm at 6 weeks and 14 weeks of age. The intradermal route exploits the rich dermal antigen-presenting cells, producing seroconversion comparable to a full intramuscular dose. Full-dose IPV is 0.5 mL intramuscularly, which describes the conventional schedule rather than the fractional schedule.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.