Which statement best describes the replication requirement of Hepatitis D virus (delta agent)?
- A It requires Hepatitis B surface antigen for its assembly and propagation ✓
- B It replicates independently using its own RNA polymerase
- C It requires Hepatitis C virus coinfection for replication
- D It replicates only in the presence of Hepatitis E virus superinfection
Correct answer: A. It requires Hepatitis B surface antigen for its assembly and propagation
Explanation
Hepatitis D virus is a defective RNA virus whose outer envelope consists of Hepatitis A surface antigen supplied by helper HBV, without which it cannot assemble, propagate or infect new cells. It therefore occurs either as coinfection with HBV or as superinfection of an HBsAg carrier, and superinfection carries the higher risk of fulminant hepatitis and chronicity. Hepatitis C and E viruses play no role in its life cycle.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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