The adult fixed dose combination (FDC-4) tablet supplied under NTEP for the intensive phase of daily therapy contains which combination of drugs per tablet?
- A Isoniazid 75 mg, Rifampicin 150 mg, Pyrazinamide 400 mg, Ethambutol 275 mg ✓
- B Isoniazid 300 mg, Rifampicin 450 mg, Pyrazinamide 750 mg, Ethambutol 550 mg
- C Isoniazid 150 mg, Rifampicin 300 mg, Pyrazinamide 800 mg, Ethambutol 400 mg
- D Isoniazid 100 mg, Rifampicin 150 mg, Pyrazinamide 350 mg, Ethambutol 250 mg
Correct answer: A. Isoniazid 75 mg, Rifampicin 150 mg, Pyrazinamide 400 mg, Ethambutol 275 mg
Explanation
The adult four-drug FDC used in NTEP contains isoniazid 75 mg, rifampicin 150 mg, pyrazinamide 400 mg and ethambutol 275 mg per tablet, with the number of tablets determined by patient weight bands rather than individual drug dosing. This weight band based dispensing replaced loose drug combinations to reduce monotherapy errors and pill burden. The other options quote arbitrary strengths not manufactured under the programme.
Reference: Guidelines for Programmatic Management of Drug Resistant Tuberculosis in India, MoHFW, 2021 ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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