As per the National Tuberculosis Elimination Programme, multidrug-resistant tuberculosis (MDR-TB) is defined as resistance to:
- A Rifampicin alone
- B Isoniazid and ethambutol
- C Isoniazid and rifampicin ✓
- D Any three first-line anti-tubercular drugs
Correct answer: C. Isoniazid and rifampicin
Explanation
MDR-TB is defined by WHO and NTEP as Mycobacterium tuberculosis resistant to at least isoniazid and rifampicin, the two most potent first-line drugs. Resistance to rifampicin alone is termed RR-TB and is managed on the same lines as MDR-TB because rifampicin monoresistance frequently coexists with occult isoniazid resistance. Pre-XDR and XDR-TB are separate categories defined by additional fluoroquinolone and bedaquiline or linezolid resistance.
Reference: Park's Textbook of Preventive and Social Medicine, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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