For a case of acute flaccid paralysis to be classified as having adequate stool specimens under polio eradication standards, which set of criteria must be met?
- A Two samples collected 24 hours apart, any time after onset, each of any quantity
- B Two samples collected at least 24 hours apart, within 14 days of onset of paralysis, each of sufficient quantity and arriving in good condition at the laboratory ✓
- C Three samples collected on alternate days within 7 days of onset
- D Two samples collected within 48 hours of onset of paralysis, each at least 2 grams
Correct answer: B. Two samples collected at least 24 hours apart, within 14 days of onset of paralysis, each of sufficient quantity and arriving in good condition at the laboratory
Explanation
Adequate stool specimens are defined as two samples collected at least 24 hours apart, ideally within 14 days of onset of paralysis, each of adequate quantity (about 8 grams) and transported in good condition to an accredited laboratory. Collecting too early misses peak viral shedding, and a single sample halves sensitivity, which is why the two-sample rule within the 14-day window is the global audit standard.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.