A 28-year-old pregnant woman in her third trimester presents with fever, jaundice, and altered sensorium. Hepatitis E IgM is positive. What is the approximate case-fatality rate for hepatitis E in this population?
- A 30-50%
- B 15-25% ✓
- C 5-10%
- D 1-3%
Correct answer: B. 15-25%
Explanation
Hepatitis E has a uniquely high case-fatality rate of 15-25% in pregnant women, especially during the third trimester, due to fulminant hepatitis. This contrasts with the general population mortality of 1-3%. The mechanism involves hormonal and immunological changes of pregnancy. Option D represents general population mortality. Options C and A are incorrect ranges not supported by epidemiological data.
Reference: Park's Textbook of Preventive and Social Medicine, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.