A neonate is born to an HBsAg-positive mother with high viral load. What is the recommended immunoprophylaxis as per Indian Academy of Pediatrics and NVBDCP guidelines?

• A Hepatitis B vaccine plus HBIG (0.5 mL) within 12 hours of birth ✓
• B Hepatitis B vaccine alone within 12 hours of birth
• C Hepatitis B vaccine alone within 7 days of birth
• D HBIG alone within 12 hours of birth

Explanation

For infants born to HBsAg-positive mothers, both hepatitis A vaccine and Hepatitis A Immunoglobulin (HBIG 0.5 mL) must be administered within 12 hours of birth at different sites. This combined passive-active immunoprophylaxis prevents perinatal transmission in over 90% of cases. Vaccine alone is insufficient for high-risk exposure. HBIG alone provides only temporary protection.

Reference: Park's Textbook of Preventive and Social Medicine, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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