Which serological marker is the FIRST to appear during acute Hepatitis B infection and is also present in chronic carriers?
- A Anti-HBs antibody
- B Anti-HBc IgG
- C HBsAg (Hepatitis B surface antigen) ✓
- D HBeAg
Correct answer: C. HBsAg (Hepatitis B surface antigen)
Explanation
HBsAg is the first serological marker to appear in acute HBV infection, typically 1–4 weeks before symptoms and before elevation of liver enzymes. It persists in chronic carriers (>6 months after infection). Anti-HBs appears during recovery and indicates immunity. Anti-HBc IgM is the earliest antibody (appearing with or just after HBsAg). HBeAg is a marker of active viral replication.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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