The National Viral Hepatitis Control Programme (NVHCP) in India aims to eliminate hepatitis B and C by 2030. Which seromarker is used to confirm 'cured' status for Hepatitis C after treatment with Direct-Acting Antivirals (DAAs)?
- A HCV RNA undetectable at 12 weeks post-treatment completion (Sustained Virological Response — SVR12) ✓
- B Anti-HCV antibody negativity at 12 weeks post-treatment
- C HCV core antigen negativity at end of treatment
- D Normal ALT and AST levels at 6 months post-treatment
Correct answer: A. HCV RNA undetectable at 12 weeks post-treatment completion (Sustained Virological Response — SVR12)
Explanation
SVR12 (Sustained Virological Response at 12 weeks post-treatment) — defined as undetectable HCV RNA by PCR at 12 weeks after treatment completion — is the standard definition of cure for hepatitis C. Anti-HCV antibodies remain positive for life after infection (even after cure) so cannot confirm cure. Normalization of liver enzymes is a supportive finding but not the definitive cure marker.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.