In cholera management, the WHO recommended first-line antibiotic for adult patients with severe cholera is:

• A Tetracycline 500 mg QID for 3 days
• B Azithromycin 500 mg OD for 3 days
• C Ciprofloxacin 1g single dose
• D Doxycycline 300 mg single dose ✓

Explanation

Doxycycline 300 mg single oral dose is the WHO first-line antibiotic for adults with cholera requiring antibiotic therapy (i.e., those with moderate-to-severe dehydration), reducing the duration and volume of diarrhoea by reducing V. cholerae stool carriage. Azithromycin is preferred for pregnant women and children due to tetracycline contraindications. Antibiotics are adjunctive; oral/IV rehydration remains the cornerstone of treatment.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.