In the WHO classification of Hepatitis B serological markers, a patient shows: HBsAg negative, anti-HBs positive, anti-HBc positive (total). This pattern is MOST consistent with:
- A Past natural infection with recovery and immunity ✓
- B Vaccination against Hepatitis B
- C Acute Hepatitis B infection in window period
- D Chronic inactive carrier state
Correct answer: A. Past natural infection with recovery and immunity
Explanation
HBsAg negative + anti-HBs positive + anti-HBc positive indicates past natural infection with recovery; anti-HBc is present because the person was infected (vaccination only produces anti-HBs without anti-HBc). Vaccination produces only anti-HBs without anti-HBc. Window period shows only anti-HBc (IgM) positive without HBsAg or anti-HBs.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.