Physiology · Respiratory Physiology (Mechanics, Gas Exchange, PFTs, Regulation)

The largest fraction of carbon dioxide carried in systemic arterial blood is in the form of:

  • A Bicarbonate ion in plasma and red cells
  • B Carbamino compounds bound to haemoglobin
  • C Physically dissolved CO2 in plasma
  • D Carbonic acid
Correct answer: A. Bicarbonate ion in plasma and red cells

Explanation

About 70 percent of transported CO2 travels as bicarbonate generated by carbonic anhydrase inside red cells, followed by the chloride shift. Carbamino-haemoglobin carries roughly 20 to 23 percent, and physically dissolved CO2 about 7 percent. The most tempting distractor is dissolved CO2: although CO2 is far more soluble than O2, its absolute dissolved fraction still remains small compared with bicarbonate.

Reference: Guyton and Hall Textbook of Medical Physiology, 14th ed.

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