The frequency of GnRH pulses from the hypothalamus differentially regulates FSH and LH secretion. Which pattern of GnRH pulse frequency preferentially stimulates LH secretion?
- A Slow frequency pulses (every 2-3 hours)
- B Rapid frequency pulses (every 60-90 minutes) ✓
- C Continuous GnRH infusion
- D GnRH pulse frequency has no differential effect on FSH versus LH
Correct answer: B. Rapid frequency pulses (every 60-90 minutes)
Explanation
Rapid GnRH pulse frequency (~every 60-90 min) preferentially stimulates LH secretion, while slow frequency pulses favor FSH. Continuous GnRH infusion causes downregulation (used by GnRH agonists in clinical practice). This differential regulation is fundamental to understanding hypothalamic control of gonadotropins.
Reference: Ganong's Review of Medical Physiology, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.