Within which range of mean arterial pressure does renal autoregulation keep GFR and renal blood flow relatively constant through the intrinsic myogenic response and tubuloglomerular feedback?

• A 60 to 120 mmHg
• B 40 to 90 mmHg
• C 100 to 200 mmHg
• D 80 to 180 mmHg ✓

Explanation

Renal autoregulation maintains nearly constant GFR and renal blood flow between arterial pressures of approximately 80 and 180 mmHg. Below 80 mmHg the afferent arteriole is maximally dilated and flow falls passively; above 180 mmHg it cannot constrict further and pressure passes through. The myogenic response is the intrinsic contraction of afferent smooth muscle when stretched, complemented by tubuloglomerular feedback from the macula densa.

Reference: Guyton and Hall Textbook of Medical Physiology, 14th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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