Which anterior pituitary cell type constitutes the largest proportion (approximately 50%) of hormone-producing cells in the gland and is the source of both GH and prolactin?
- A Corticotrophs
- B Gonadotrophs
- C Somatotrophs ✓
- D Thyrotrophs
Correct answer: C. Somatotrophs
Explanation
Somatotrophs constitute approximately 50% of anterior pituitary cells and produce GH. Lactotrophs (prolactin-producing) constitute 15-25%. While GH and prolactin come from different cell types (somatotrophs and lactotrophs respectively), somatotrophs are the single most abundant cell type. Corticotrophs make up 15-20%, gonadotrophs 10-15%, and thyrotrophs about 5%.
Reference: Ganong's Review of Medical Physiology, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.