Growth hormone secretion exhibits a distinct diurnal pattern. The major peak in GH secretion normally occurs during which stage of sleep?
- A REM sleep
- B Stage N1 (light sleep)
- C Stage N3 (slow-wave sleep) ✓
- D Sleep onset regardless of stage
Correct answer: C. Stage N3 (slow-wave sleep)
Explanation
The major peak in GH secretion occurs during slow-wave sleep (stage N3, formerly stages 3 and 4), typically within the first 1-2 hours of sleep. This peak is mediated by GHRH release and coincides with the nadir in cortisol. GH secretion is minimal during REM sleep and wakefulness in normal adults.
Reference: Ganong's Review of Medical Physiology, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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