The tuberoinfundibular dopamine (TIDA) neurons project from the hypothalamic arcuate nucleus to the median eminence. Dopamine released from these neurons acts on lactotrophs via which receptor to inhibit prolactin secretion?
- A D1 receptor
- B D3 receptor
- C D2 receptor ✓
- D D4 receptor
Correct answer: C. D2 receptor
Explanation
Dopamine inhibits prolactin secretion by acting on D2 receptors on lactotroph cell membranes. This is the basis for using D2 receptor agonists (bromocriptine, cabergoline) to treat prolactinomas. D1 receptors are primarily vascular, while D3 and D4 receptors are not the main mediators of dopaminergic prolactin inhibition.
Reference: Katzung's Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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