Pro-opiomelanocortin (POMC) is a common precursor polypeptide processed differently in various tissues. In anterior pituitary corticotrophs, POMC is cleaved to produce ACTH and which other major peptide fragment?
- A Beta-endorphin
- B Alpha-MSH
- C Beta-lipotropin (beta-LPH) ✓
- D Corticotropin-like intermediate peptide (CLIP)
Correct answer: C. Beta-lipotropin (beta-LPH)
Explanation
In anterior pituitary corticotrophs, prohormone convertase 1 (PC1) cleaves POMC into ACTH and beta-LPH, along with the N-terminal fragment. Alpha-MSH and CLIP are produced in the intermediate lobe, which is rudimentary in adult humans. Beta-endorphin is derived from further processing of beta-LPH, not directly from POMC in corticotrophs.
Reference: Williams Textbook of Endocrinology, 14th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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