From which cell lineage are osteoclasts derived?

• A Hematopoietic monocyte-macrophage precursors ✓
• B Endothelial progenitor cells
• C Mesenchymal stem cells
• D Neural crest cells

Explanation

Osteoclasts arise from fusion of mononuclear precursors of the monocyte-macrophage lineage within the hematopoietic compartment, which explains why they carry macrophage markers such as CD68 and why marrow disorders can alter osteoclast function. Osteoblasts, in contrast, come from mesenchymal stem cells. This dual origin underlies the distinct regulation of the two cell types by M-CSF and RANKL.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.