Physiology · Blood Pressure and Vascular Regulation

In a hypovolemic patient, angiotensin II acts on the renal glomerular arterioles to preserve glomerular filtration rate. Which vascular effect best explains this protective mechanism?

  • A Preferential constriction of the efferent arteriole
  • B Preferential constriction of the afferent arteriole
  • C Equal constriction of afferent and efferent arterioles
  • D Prostaglandin-mediated afferent arteriolar vasodilation
Correct answer: A. Preferential constriction of the efferent arteriole

Explanation

Angiotensin II preferentially constricts the efferent arteriole, raising glomerular capillary hydrostatic pressure and maintaining GFR despite reduced renal plasma flow. This increases filtration fraction. Option C would not selectively sustain glomerular pressure. Option B would reduce glomerular pressure and worsen GFR. Option D describes a compensatory afferent dilatory mechanism (prostaglandins) seen in some hypovolemic states, but it is not the angiotensin II-mediated protective effect.

Reference: Guyton and Hall Textbook of Medical Physiology, 14th ed.

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