Physiology · Applied and Clinical Physiology Correlations (Pathophysiology Mechanisms)

Which cardiovascular reflex is specifically triggered by distension of the pulmonary vasculature and causes reflex bradycardia and hypotension (similar to Bezold-Jarisch reflex)?

  • A Bainbridge reflex
  • B Pulmonary chemoreflex (Pulmonary J-receptor reflex)
  • C Cushing reflex
  • D Carotid sinus reflex
Correct answer: B. Pulmonary chemoreflex (Pulmonary J-receptor reflex)

Explanation

The pulmonary J-receptor (juxtacapillary receptor) reflex is triggered by pulmonary capillary engorgement, inflammatory mediators, and microemboli. It causes rapid shallow breathing, bradycardia, hypotension, and laryngospasm — similar in mechanism to the Bezold-Jarisch reflex. The Bainbridge reflex causes tachycardia with atrial distension; the Cushing reflex is a hypertensive-bradycardia response to raised ICP; the carotid sinus reflex mediates baroreceptor-dependent heart rate control.

Reference: Guyton & Hall, Textbook of Medical Physiology, 14th ed.

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