Misoprostol is prescribed for prophylaxis of NSAID-induced gastric ulcers in a 55-year-old woman with osteoarthritis. Which absolute contraindication must be confirmed before starting this drug?
- A Hypertension
- B Pregnancy ✓
- C Diabetes mellitus
- D Renal calculi
Correct answer: B. Pregnancy
Explanation
Misoprostol is a synthetic PGE1 analogue that binds EP3 receptors on parietal cells to reduce acid secretion and enhances mucosal defence. It also stimulates uterine smooth muscle contraction, so it is an abortifacient and is absolutely contraindicated in pregnancy; women of childbearing potential need reliable contraception. Diarrhoea and abdominal cramping are its common dose-limiting adverse effects, not reasons for absolute avoidance.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.