A drug has a volume of distribution of 14 L and a clearance of 28 mL/min in a 70-kg patient. The elimination half-life is closest to:
- A 5.8 hours ✓
- B 2.9 hours
- C 11.6 hours
- D 23.1 hours
Correct answer: A. 5.8 hours
Explanation
t½ = (0.693 × Vd) / CL. CL = 28 mL/min = 1.68 L/hr. t½ = (0.693 × 14 L) / 1.68 L/hr = 9.702 / 1.68 = 5.78 hr ≈ 5.8 hr. The other options represent multiples or fractions of this value (2.9 hr = t½/2, 11.6 hr = 2×t½, 23.1 hr = 4×t½) and do not match the calculated value, confirming option A is correct.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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