Latanoprost eye drops are prescribed for open-angle glaucoma. The drug lowers intraocular pressure by acting on which receptor and by which mechanism?

• A Beta adrenergic receptor, decreased aqueous humour production
• B Alpha-2 adrenergic receptor, decreased aqueous humour production
• C FP prostanoid receptor, increased uveoscleral outflow ✓
• D EP3 prostanoid receptor, increased trabecular outflow

Explanation

Latanoprost is a prostaglandin F2-alpha analogue that acts on the FP prostanoid receptor of the ciliary body. It relaxes the ciliary muscle and remodels the extracellular matrix, increasing uveoscleral outflow, which lowers intraocular pressure more effectively than most other classes. Beta blockers such as timolol reduce aqueous secretion, alpha-2 agonists like brimonidine reduce secretion and increase uveoscleral flow, and pilocarpine increases trabecular outflow through the conventional pathway.

Reference: Katzung's Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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