Ketorolac is a potent NSAID used for short-term management of moderate to severe pain. Which statement about ketorolac is correct?

• A It is more potent than morphine on a milligram basis for visceral pain
• B It is the NSAID of choice in patients on anticoagulants due to its minimal antiplatelet effect
• C It selectively inhibits COX-2 and has minimal GI side effects
• D Its use is restricted to a maximum of 5 days (parenteral plus oral combined) due to risk of serious GI and renal toxicity ✓

Explanation

Ketorolac is a potent non-selective NSAID with significant GI and renal toxicity. Its duration of use is limited to a maximum of 5 days (combined parenteral and oral) due to risk of serious adverse effects including GI bleeding, perforation, and renal failure. It is not more potent than morphine. It is non-selective for COX, not COX-2 selective. It impairs platelet function and is avoided in patients on anticoagulants.

Reference: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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