Which NSAID is used specifically to promote closure of a patent ductus arteriosus in a preterm neonate?
- A Indomethacin ✓
- B Naproxen
- C Diclofenac
- D Piroxicam
Correct answer: A. Indomethacin
Explanation
Indomethacin inhibits prostaglandin synthesis, and prostaglandins (particularly PGE) maintain ductal patency in the fetus and neonate. Suppressing their production allows the ductus arteriosus to close. Ibuprofen has also been used for this purpose with fewer renal side effects, but among the listed options only indomethacin is the established agent. Naproxen, diclofenac and piroxicam are used for inflammatory pain and are not employed for ductal closure.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.