Unlike loop diuretics, thiazide diuretics are associated with which of the following electrolyte disturbances?

• A Hyperkalemia
• B Hypercalciuria
• C Hypomagnesemia
• D Hypercalcemia ✓

Explanation

Thiazides reduce urinary calcium excretion by increasing calcium reabsorption in the proximal tubule and distal convoluted tubule. This can cause mild hypercalcemia, which is useful in preventing calcium stones in idiopathic hypercalciuria. In contrast, loop diuretics increase calcium excretion and cause hypercalciuria. Thiazides also cause hypokalemia and can cause hyponatremia.

Reference: Katzung Basic & Clinical Pharmacology, 14th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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