A patient with acute glomerulonephritis presents with oliguria and a serum creatinine of 4.2 mg/dL. Mannitol is considered for suspected cerebral edema. Which finding is an absolute contraindication to mannitol administration?

• A Anuria due to renal failure ✓
• B Hypernatremia
• C Hypertension
• D Hypokalemia

Explanation

Mannitol is filtered at the glomerulus but not reabsorbed, so it requires adequate renal function for elimination. In anuria or severe renal failure, mannitol accumulates in plasma, drawing fluid from cells into the vascular compartment, which can precipitate pulmonary edema and volume overload. Hypertension and hypernatremia are relative concerns but not absolute contraindications. Hypokalemia is unrelated to mannitol use.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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