A patient with heart failure is started on a diuretic that specifically blocks the vasopressin V1a receptor. Which drug acts through this mechanism?

• A Tolvaptan
• B Satavaptan
• C Mozavaptan
• D Conivaptan ✓

Explanation

Conivaptan is a non-selective vasopressin receptor antagonist that blocks both V1a and V2 receptors. Tolvaptan, mozavaptan, and satavaptan are selective V2 receptor antagonists. V1a receptors mediate vasoconstriction and myocardial hypertrophy, while V2 receptors regulate water reabsorption in the collecting duct.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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