Mannitol is contraindicated in which of the following clinical scenarios?
- A Acute angle-closure glaucoma
- B Cerebral edema with increased intracranial pressure
- C Anuric acute kidney injury ✓
- D Rhabdomyolysis with myoglobinuria
Correct answer: C. Anuric acute kidney injury
Explanation
Mannitol is filtered at the glomerulus and excreted unchanged in urine. In anuric renal failure, mannitol cannot be excreted and accumulates in plasma, causing expansion of extracellular volume and potentially precipitating pulmonary edema and heart failure. It requires adequate renal function to work.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.