Acetazolamide is used in the treatment of open-angle glaucoma. The mechanism by which it reduces intraocular pressure is:
- A Inhibition of carbonic anhydrase in the ciliary epithelium reducing aqueous humor production ✓
- B Vasoconstriction of ciliary body blood vessels reducing aqueous humor production
- C Increased outflow of aqueous humor through the trabecular meshwork
- D Osmotic dehydration of the vitreous humor
Correct answer: A. Inhibition of carbonic anhydrase in the ciliary epithelium reducing aqueous humor production
Explanation
Acetazolamide inhibits carbonic anhydrase in the ciliary epithelium of the eye, reducing aqueous humor production and thereby lowering intraocular pressure. This is the same mechanism by which it acts in the proximal tubule. It is used in acute angle-closure glaucoma and as adjunctive therapy in open-angle glaucoma.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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