A patient with a documented severe sulfonamide allergy requires a loop diuretic for acute pulmonary edema. Which loop diuretic is safe to administer in this patient?

• A Furosemide
• B Bumetanide
• C Torsemide
• D Ethacrynic acid ✓

Explanation

Ethacrynic acid is the only loop diuretic that is not a sulfonamide derivative. Furosemide, bumetanide, and torsemide all contain sulfonamide moieties and should be avoided in patients with severe sulfa allergy. Ethacrynic acid is a phenoxyacetic acid derivative and can be used as an alternative.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.