Which potassium sparing diuretic has been reported to precipitate as kidney stones, particularly in patients predisposed to urolithiasis?
- A Spironolactone
- B Triamterene ✓
- C Eplerenone
- D Amiloride
Correct answer: B. Triamterene
Explanation
Triamterene and its metabolites are poorly soluble and have been documented to crystallize as urinary calculi, sometimes forming the nidus of mixed stones. Patients with preexisting stones or concentrated urine are at higher risk. Amiloride, being structurally distinct and more soluble, is preferred in patients who need an epithelial sodium channel blocker and have a history of nephrolithiasis.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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