The nomenclature of monoclonal antibodies encodes their source. A newly introduced antibody named with the suffix '-zumab' indicates that it is:

• A Humanized ✓
• B Chimeric mouse-human
• C Fully murine
• D Fully human

Explanation

In monoclonal antibody nomenclature, the sub-stem before 'mab' denotes origin: -omab is murine, -ximab is chimeric (e.g., rituximab, cetuximab), -zumab is humanized (e.g., trastuzumab, bevacizumab), and -umab is fully human (e.g., panitumumab, nivolumab). Humanized antibodies have only the complementarity-determining regions derived from mouse sequences grafted onto a human framework. Fully human antibodies carry the -umab suffix, which kills distractor D.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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