Danazol prescribed for endometriosis produces symptom relief but is often abandoned because of adverse effects. Which set of adverse effects correctly matches its pharmacology?

• A Weight gain, acne, hirsutism, and irreversible deepening of voice ✓
• B Gynaecomastia, galactorrhoea, and hyperkalaemia
• C Osteoporosis, hot flushes, and vaginal atrophy only
• D Hyperkalaemia, hypertension, and pedal oedema

Explanation

Danazol is a weak androgen derived from ethisterone that suppresses the midcycle LH and FSH surge, creating a hypoestrogenic environment. Residual androgenic activity causes weight gain, acne, oily skin, hirsutism, and occasionally irreversible voice change, which limits long-term use. Hyperkalaemia points to spironolactone-like drugs, and pure hypoestrogenic features ignore danazol's androgen component.

Reference: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th ed.

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Written and medically reviewed by the StethoPrep medical team.