Long-term therapy with which of the following alkylating agents is characteristically associated with progressive pulmonary fibrosis along with generalized skin hyperpigmentation?
- A Busulfan ✓
- B Melphalan
- C Chlorambucil
- D Thiotepa
Correct answer: A. Busulfan
Explanation
Busulfan, historically used in chronic myeloid leukemia, produces the classic combination of diffuse interstitial pulmonary fibrosis termed busulfan lung together with slate-grey hyperpigmentation of the skin, reflecting its effect on melanocytes. Melphalan and chlorambucil are mainly limited by myelosuppression, and thiotepa by myelosuppression with mucositis. Pulmonary fibrosis is the signature late toxicity that distinguishes busulfan among classical alkylators and makes it a repeatedly examined association.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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