Pharmacology · Cardiovascular Drugs (Antihypertensives, Anti-Anginals, Heart Failure, Anti-Arrhythmics)

Which class IB sodium channel blocker is used for ventricular arrhythmias, especially post-myocardial infarction, and can cause dose-dependent central nervous system toxicity such as seizures?

  • A Amiodarone
  • B Flecainide
  • C Sotalol
  • D Lidocaine
Correct answer: D. Lidocaine

Explanation

Lidocaine is a class IB antiarrhythmic that shortens action potential duration and is effective for ventricular arrhythmias. Its toxic effects include drowsiness, paresthesias, and seizures. Flecainide is class IC, while sotalol and amiodarone are class III agents with different toxicity profiles.

Reference: Katzung's Basic & Clinical Pharmacology, 15th ed.

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