A 60-year-old man with stable angina is being considered for anti-anginal therapy. Which of the following beta-blockers is contraindicated in angina due to its intrinsic sympathomimetic activity?
- A Pindolol ✓
- B Metoprolol
- C Atenolol
- D Bisoprolol
Correct answer: A. Pindolol
Explanation
Pindolol is a non-selective beta-blocker with intrinsic sympathomimetic activity (ISA). Its partial agonist effect can increase heart rate and myocardial oxygen demand, worsening angina. Atenolol, metoprolol, and bisoprolol are selective beta-1 blockers without ISA and are safe in angina.
Reference: Katzung's Basic & Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.