Which of the following sympathomimetics is used in the management of neurogenic orthostatic hypotension because it releases noradrenaline from sympathetic nerve terminals?
- A Midodrine
- B Droxidopa ✓
- C Tyramine
- D Phenylephrine
Correct answer: B. Droxidopa
Explanation
Droxidopa (L-DOPS) is a synthetic amino acid prodrug that is peripherally converted to noradrenaline by dopa-decarboxylase; it replenishes noradrenaline in sympathetically denervated patients, raising standing BP. Midodrine is a direct alpha-1 agonist prodrug. Tyramine also releases catecholamines but is not used therapeutically and can cause dangerous interactions with MAOIs.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.