Which of the following beta-blockers undergoes extensive first-pass metabolism, has the shortest half-life, and is used as an IV agent to control perioperative supraventricular tachycardia?
- A Atenolol
- B Esmolol ✓
- C Metoprolol
- D Carvedilol
Correct answer: B. Esmolol
Explanation
Esmolol is an ultra-short-acting cardioselective beta-1 blocker with a plasma half-life of approximately 9 minutes; it is rapidly hydrolysed by red blood cell esterases (not hepatic CYP450). Its titratable IV formulation makes it the agent of choice for perioperative SVT, thyroid storm, and aortic dissection. Atenolol is renally excreted with a long half-life; metoprolol and carvedilol are orally administered.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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