A patient has an infection caused by Acinetobacter baumannii. Which beta-lactamase inhibitor has intrinsic bactericidal activity against this organism, independent of its enzyme inhibitory action?

• A Clavulanic acid
• B Tazobactam
• C Avibactam
• D Sulbactam ✓

Explanation

Sulbactam is a beta-lactamase inhibitor that also has intrinsic bactericidal activity against Acinetobacter baumannii by binding to penicillin-binding proteins. Clavulanic acid, tazobactam, and avibactam lack this intrinsic anti-Acinetobacter activity. The combination of ampicillin and sulbactam is frequently used for such multidrug-resistant infections. It provides both enzyme inhibition and direct antibacterial action.

Reference: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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