A 60-year-old man with myasthenia gravis is diagnosed with community-acquired pneumonia. Which antibiotic should be avoided due to its neuromuscular blocking activity?
- A Ciprofloxacin
- B Clindamycin
- C Gentamicin ✓
- D Azithromycin
Correct answer: C. Gentamicin
Explanation
Gentamicin, an aminoglycoside, inhibits presynaptic acetylcholine release and can precipitate myasthenic crisis. Fluoroquinolones and macrolides have some risk, but aminoglycosides are the classic agents to avoid in myasthenia gravis. Clindamycin does not cause neuromuscular blockade.
Reference: Katzung: Basic & Clinical Pharmacology, 14th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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