Fluoroquinolones are contraindicated in children because of which specific toxicity demonstrated in animal studies?
- A Hepatotoxicity with irreversible cholestasis
- B Damage to weight-bearing cartilage (arthropathy) ✓
- C Ototoxicity with permanent sensorineural deafness
- D Optic neuritis causing visual impairment
Correct answer: B. Damage to weight-bearing cartilage (arthropathy)
Explanation
Fluoroquinolones cause damage to weight-bearing joint cartilage (arthropathy) in juvenile animal models, likely due to chelation of magnesium in cartilage matrix. This is why they are generally contraindicated in children and adolescents below 18 years and in pregnant/lactating women. Ototoxicity is a known adverse effect of aminoglycosides. Optic neuritis is associated with ethambutol. Cholestatic hepatitis is seen with some macrolides.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.