Ceftaroline differs from earlier-generation cephalosporins principally because it:
- A Inhibits bacterial DNA gyrase in addition to transpeptidase
- B Has activity against MRSA due to binding affinity for the altered PBP2a ✓
- C Is stable against extended-spectrum beta-lactamases (ESBLs) via a 1-methyl group
- D Acts synergistically with aminoglycosides by inhibiting the 30S ribosomal subunit
Correct answer: B. Has activity against MRSA due to binding affinity for the altered PBP2a
Explanation
MRSA resistance to beta-lactams results from the mecA gene-encoded PBP2a (PBP2'), which has very low affinity for conventional beta-lactams. Ceftaroline (a 5th-generation cephalosporin) possesses a unique side chain conferring high binding affinity for PBP2a, thereby inhibiting cell-wall synthesis in MRSA. It is currently the only beta-lactam approved for MRSA skin and soft tissue infections and community-acquired pneumonia.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.