Which fluoroquinolone is classified as a 'respiratory fluoroquinolone' and is considered most active against Streptococcus pneumoniae due to its enhanced anti-pneumococcal potency?
- A Ciprofloxacin
- B Moxifloxacin ✓
- C Norfloxacin
- D Enoxacin
Correct answer: B. Moxifloxacin
Explanation
Moxifloxacin (and levofloxacin) are 'respiratory fluoroquinolones' with excellent activity against S. pneumoniae, atypicals, and anaerobes, due in part to enhanced affinity for DNA gyrase and topoisomerase IV of Gram-positives. Ciprofloxacin has poor anti-pneumococcal activity and should not be used for CAP monotherapy. Norfloxacin and enoxacin are older quinolones with limited systemic bioavailability and no respiratory indication.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.