A 28-year-old man with extensive tinea capitis is started on an oral antifungal that accumulates in keratin precursor cells and disrupts the mitotic spindle by binding to tubulin. Which drug is described?
- A Terbinafine
- B Griseofulvin ✓
- C Fluconazole
- D Itraconazole
Correct answer: B. Griseofulvin
Explanation
Griseofulvin binds to tubulin and disrupts the mitotic spindle, inhibiting fungal mitosis. It is deposited in keratin precursor cells, making it effective for dermatophyte infections of skin, hair, and nails. Terbinafine inhibits squalene epoxidase, while fluconazole and itraconazole inhibit lanosterol 14-alpha-demethylase (ergosterol synthesis).
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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