Griseofulvin exerts its antifungal effect against dermatophytes by which mechanism?
- A Inhibition of beta-glucan synthesis in the cell wall
- B Inhibition of ergosterol synthesis at the squalene epoxidase step
- C Inhibition of fungal mitosis by binding tubulin and disrupting microtubules ✓
- D Formation of pores in the fungal cell membrane
Correct answer: C. Inhibition of fungal mitosis by binding tubulin and disrupting microtubules
Explanation
Griseofulvin binds fungal tubulin and prevents microtubule assembly, arresting mitosis at metaphase. It deposits in keratin precursor cells and is used for dermatophyte infections of skin, hair and nails. It has no activity against yeasts such as Candida, and its mechanism is entirely distinct from membrane pore formation by amphotericin B.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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